The Kansas City Chiefs are set to clash with the Buffalo Bills at Highmark Stadium in Orchard Park on November 2, 2025, with kickoff scheduled for 4:25 PM.

In the 2024 NFL season, the Kansas City Chiefs secured the 2nd spot in their division and 7th across their conference, sporting a 2-2-0 record which translates to a 0.500 winning percentage. They’ve accumulated 97 points so far while conceding 76, resulting in a positive net points difference of 21. In contrast, the Buffalo Bills are leading their division and conference with a perfect 4-0-0 record, exhibiting a winning percentage of 1.000. They have outscored their opponents 133 to 90, earning a net points difference of 43.

In their previous encounter, the Chiefs overcame the SF with a 28-18 victory at Levi’s Stadium, marking 22 first downs and amalgamating 184 rushing yards with 145 passing yards. On the other side, the Bills dominated the TEN in a 34-10 triumph at Highmark Stadium, accumulating 18 first downs, 74 rushing yards, and an impressive 315 passing yards.

Quarterback performances have been pivotal, with Patrick Mahomes of the Chiefs throwing for 154 yards and a passer rating of 44.37 in their last game, while Josh Allen of the Bills showcased a stellar performance with 323 passing yards, two touchdowns, and a passer rating of 116.1.

As both teams gear up for this anticipated matchup, the odds reflect a keen contest. The Buffalo Bills are favored with a point spread of -2.50, indicating expectations for a close game. The total points (over/under) set for the match is 48.70, pointing towards expectations of a moderately high-scoring game. In terms of straight win probabilities, the moneyline odds are -143 for the home team, the Buffalo Bills, and +121 for the visiting Kansas City Chiefs.

For avid NFL fans and bettors, this game promises excitement and is a crucial one to watch, given the current form and stakes at play.